DNAlysis Health/Mind and Organic Acid Test Conclusion

 

PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.

 

First, we did the Methylation test, because we did not know it was part of the DNAlysis Health test, then we did the Organic Acid test, and then we did the full DNAlysis Health and Mind test.

Some questions you might ask:

1. Could doing these tests even collaborate or support each other’s findings, even so far apart in time?
2. Is it worth it? Does knowing the inner workings of the body and mind cure a disease or condition?
3. So, what was the conclusion?

Let’s start with Question 2:

Is it worth it? Does knowing the inner workings of the body and mind cure a disease or condition?

Some might say, No – it is a waste of money; it’s only a money-making scheme.

Some might say, Yes – It helps discover underlying imbalances, it helps manage or alleviate symptoms.

While Nutrigenomic testing doesn’t cure Autism or ADHD, it helps us understand your child’s unique biology, so you can better support their needs and reduce the daily struggles, because so many co-morbidities and imbalances could be alleviated through nutrition and lifestyle changes.

Question 1: Could doing these tests even collaborate or support each other’s findings, even so far apart in time?

1. Genes Influence How Our Body Processes Nutrients

• Genetic variants (like MTHFR, MTRR, or CBS) affect enzyme function, sometimes reducing how well the body converts folate, B12, or handles homocysteine.

• These changes often leave metabolic footprints, which we can detect through tests like OAT.

2. Organic Acids Reflect Real-Time Functional Status

• Unlike genes, which don’t change, organic acid levels fluctuate in response to gene function, diet, gut health, and environment.

• Low levels or imbalances in energy or detox markers (e.g., low Krebs cycle intermediates, low glutathione precursors) reflect the downstream effect of genetic limitations.

3. Studies Show Strong Molecular Overlap

• Research from genome-wide metabolomics finds that common SNPs in enzyme genes explain a significant part (up to ~28%) of variability in metabolite levels, especially when they map to enzyme activity.

• This means a gene variant that affects an enzyme often produces a measurable metabolite signal that reflects how well that enzyme is functioning.

4. Genetics + Metabolomics = A Power Combo

• Genomic data gives insight into predispositions (what genes might impair).

• Metabolomics (like OAT) shows what is happening in real time—how genes are expressed under the current diet, environment, gut microbiome, etc.

Example: Connecting the Dots in Alex’s Case

• Genetic Report (2022) found:

  • MTHFR 677 TT, MTRR, MTR variants → reduced methylation and homocysteine clearance

  • GSTM1 deletion, GSTP1, NQO1 variants → impaired detox and weaker antioxidant pathways

• Organic Acids Test (2019) showed:

  • Low B6 and vitamin C markers, low NAC & CoQ10 → confirming methylation/detox support was lacking

  • Krebs cycle markers low, glutathione markers low → confirming mitochondrial and detox impairment

Together, these indicate that genetic vulnerabilities are expressed in real-time metabolic dysfunction, validating the genomic predictions.

Question 3: So, what was the conclusion?

Alex has genetic predispositions that affect:

• Methylation

• Detoxification

• Oxidative stress protection

• Cholesterol and insulin sensitivity

• Vitamin handling (B12, B6, folate, vitamin D, vitamin A)

These genetic “weak spots” are functionally active, as confirmed by the Organic Acids Test, which shows:

• Low levels of key nutrients (B6, C, CoQ10, NAC)

• Reduced energy metabolism

• Detox challenges (especially glutathione production)

• Yeast overgrowth and gut imbalance

• Signs of neurotransmitter imbalances

In other words:
His genes create a higher need for certain nutrients and metabolic support, and the Organic Acids Test shows that these needs are not being met, which may be contributing to fatigue, focus issues, immune imbalance, and behavioural symptoms.

KEY FUNCTIONAL AREAS TO SUPPORT

1. Methylation & B-Vitamin Support

• Genetic: MTHFR TT, MTRR AG, MTR AG

• OAT: Low B6, signs of methylation stress

• Support with:

  • Methylated folate (L-5MTHF)

  • Methylcobalamin (B12)

  • P5P (active B6)

  • Choline (e.g., Alpha-GPC)

2. Glutathione & Detoxification

• Genetic: GSTM1 deleted, GSTP1, NQO1 variants

• OAT: NAC = BDL, low glutathione markers

• Support with:

  • NAC or glycine + glutamine

  • Selenium + milk thistle

  • Broccoli, garlic, and cruciferous veg

  • Reduce toxin exposure (food, environment, mould)

3. Oxidative Stress

• Genetic: SOD2 TT, GPX1 CT

• OAT: Low CoQ10, low vitamin C

• Support with:

  • CoQ10 (ubiquinol), vitamin C, vitamin E

  • Polyphenol-rich foods (berries, green tea)

4. Energy / Mitochondrial Function

• Genetic: Secondary effects from methylation and oxidative stress genes

• OAT: Low Krebs cycle intermediates

• Support with:

  • B-complex

  • Magnesium

  • CoQ10

  • Carnitine-rich foods (or supplement if needed)

5. Gut Health

• OAT: High yeast/fungal markers, low GABA, high phenolic acids

• Support with:

  • Low-sugar, low-yeast diet

  • Probiotics: Lactobacillus rhamnosus, Bifidobacterium

  • Natural antifungals: oregano oil, caprylic acid (under supervision)

  • Fibre-rich, prebiotic foods

6. Vitamin-Specific Needs

7. Neurotransmitter & Mood Support

• COMT A allele, MAO-A variations (from DNA report)

• OAT: Low GABA, borderline HVA/VMA ratio (dopamine/norepinephrine)

• Support with:

  • Magnesium (200–400 mg/day, citrate or glycinate)

  • B6 (P5P)

  • Choline (for acetylcholine production)

  • Gentle adaptogens (e.g., rhodiola or L-theanine)

ACTION PLAN SUMMARY

Foods:

GOALS OF THIS PLAN:

1. Support methylation and nutrient gaps (B6, B12, folate, vitamin C, choline, CoQ10, vitamin A)

2. Support detox and antioxidant function (glutathione, NAC, selenium, polyphenols)

3. Reduce yeast overgrowth and gut inflammation

4. Improve energy and mood

DAILY DIET FRAMEWORK

🥬 Vegetables (Daily: 6+ servings)

Boosts folate, antioxidants, fibre, and supports detox.

• Eat raw or lightly steamed: spinach, rocket, parsley, kale, romaine

• Steamed or sautéed (light olive oil or ghee): broccoli, cauliflower, carrots, beetroot, green beans

• Roasted or grilled: sweet potato, squash, zucchini, red peppers

🌡️ Best cooking method:

• Light steaming (preserves folate & B vitamins)

• Roasting/grilling with healthy fats (enhances absorption of fat-soluble nutrients like vitamin A)

🍳 Proteins (Each Meal)

Supports methylation, neurotransmitters, and detox.

• Eggs (boiled, scrambled, poached – avoid deep frying)

• Chicken/turkey (grilled, baked, or steamed – avoid crumbed/fried)

• Oily fish (like sardines or salmon – grilled, baked in foil)

• Lentils, chickpeas (stewed or added to soups/curries)

• Tofu or tempeh (lightly sautéed or baked)

🌡️ Best cooking method:

• Grilled, baked, poached, or lightly pan-fried (in olive oil or avocado oil)

🥑 Healthy Fats

Supports brain, hormones, and detox.

• Avocado (raw)

• Extra virgin olive oil (drizzle on cooked food or use for light sauté)

• Chia seeds, flaxseed (ground; sprinkle on porridge or smoothies)

• Walnuts, almonds (soaked or roasted; avoid salted)

🌡️ Best usage:

• Use cold (olive oil) or low-heat sauté (ghee, avocado oil)

🍚 Complex Carbs (1–2 servings/day)

Supports energy without feeding yeast.

• Sweet potato (baked or steamed)

• Quinoa (boiled)

• Brown rice (soaked overnight, cooked with a pinch of salt and oil)

• Oats (soaked and cooked slowly, or overnight oats)

🌡️ Best cooking method:

• Boil or steam – avoid fried rice or sugar-laden porridge

🍇 Fruits (1–2 servings/day, low-glycemic only)

• Blueberries, strawberries (raw or in smoothies)

• Apple (raw or stewed with cinnamon)

• Citrus (vitamin C support – oranges, lemon, lime)

🌡️ Best usage:

• Raw is fine, or lightly stewed to reduce fermentation in the gut

🧄 Gut & Detox Foods (daily)

• Garlic & onions (lightly sautéed or roasted)

• Fermented foods: sauerkraut, unsweetened coconut yoghurt (if tolerated)

• Broccoli sprouts (raw or gently steamed)

🍵 Herbal Teas & Broths

• Dandelion root or milk thistle tea (liver support)

• Rooibos (antioxidants)

• Homemade veggie broth (mineral-rich; drink as a warm evening support)

❌ FOODS TO AVOID

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🍽️ HOW TO EAT

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🧪 WEEKLY FOOD ADDITIONS (ROTATE IN)

Final Guidance 

• His genes give us a map of where his body needs extra help.

• The Organic Acids Test confirms that many of those systems are under strain right now.

• With targeted nutrition, supplements, and lifestyle changes, you can support his mood, behaviour, focus, detox ability, and overall vitality.

 

PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.