Please note: The content of this post is my own, unless the technical terms is too hard to explain, then the content is copy and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery. 

Found this really cool picture on that explains what the Methylation Cycle does:

But we want to look at the Folate Cycle – MTHFR C667T and A1298C:

Fitting this picture, the explanation of the Folate cycle is described as:

“The Folate Cycle is the “Organic Farming Region” where everything is homegrown. This Region grows “organic” work tags (methyl groups) and is instrumental in the front-line production of new RNA and DNA. Still, this plantation is a bit old fashioned, employing a chain gang (homocysteine) to help them get the work done. Though rarely considered in everyday life, RNA & DNA are essential to making you unique, as well as directing health and longevity. Despite this, there must be balance between available work tags and crafting new genetic code. ” (

So lets look at Alex’s results for MTHFR C667T and A1298C:

From a previous post you would remember that the clear markers mean there were no effect from this gene, but as you can see his C667T is not looking too good with 3 blue markers and the double T (TT). What does that mean?

Firstly the “T” is called allele. An Allele is one of two or more alternative forms of a gene that arise by mutation and are found at the same place on a chromosome. An TT allele lowers the activity of the MTHFR enzyme and increase the homocynsteine levels. Secondly, this means that there is less DNA repair and an increase in DNA adducts. An Adduct is a segment of DNA connected to a cancer-causing chemical. The TT results means that your MTHFR enzyme function is only at 40%. Thirdly,  an T allele carrier have increased folate, B2, B6 and B12 requirements.

To keep this whole process going B2 must be present in high enough amounts in the body to allow other B vitamins including B6 and folic acid to properly do their jobs.

The Folate cycle is huge and has many other steps involved. It produce Serine, Sarcosine and Glycine. And continue into the MAO & COMT and Urea Cycle. From the COMT cycle you have Neurotransmitter Metabolism (melatonin, Serotonin, Dopamine and Adrenaline) and Hystamine Metabolism. The Urea Cycle are responsible for Purines, Oxalate production and Nitric Oxide Production. The Urea/ Citric acid cycle also have Vit B3 (Niacin) involved.

Vitamin B3

The body uses vitamin B3 in the process of releasing energy from carbohydrates. Vitamin B3 comes in two basic forms- niacin (also called nicotinic acid) and niacinamide (also called nicotinamide). Niacin is involved in the production of NAD, required for redox reactions in glycolysis and in Krebs cycle during oxidative phosphorylation.

Vitamin D and VDR receptors

And somewhere in there Vitamin D plays a big roll.

Virtually every tissue type in your body has receptors for vitamin D, meaning that they all require vitamin D for adequate functioning. The very presence of specific receptors define vitamin D as a hormone, rather than a vitamin. It interacts with receptors throughout the body and has a number of different effects.

It’s becoming evident that higher doses of vitamin D are required to support its other activities in tissues such as heart muscle, brain cells, and fat tissue, to name just a few. Additionally, vitamin D regulates genes that control cell growth and development, immune function, and metabolic control.

Studies have now shown that vitamin D deficiency is associated with increased risk of numerous chronic disorders, including type II diabetes, cancer, infections, and cardiovascular, autoimmune, and neurological diseases.

While humans can make some vitamin D in their bodies, most of us require additional amounts from our diet, the sun, or from supplements in order to maintain adequate levels.

Once vitamin D has been ingested in the diet or produced in the skin, the liver and kidneys convert it to its active form, called 1,25-dihydroxyvitamin D, or vitamin D3.

According to mainstream medical standards, there are three levels of vitamin D status: sufficient, insufficient, and deficient.

  • People who are considered vitamin D “sufficient” have blood levels of at least 30 ng/mL. However, optimal vitamin D status is achieved with a minimum of 50 ng/mL.
  • Those considered “insufficient” (meaning their bodies aren’t at optimal vitamin D capacity) have levels between 21 and 29 ng/mL.
  • And those who are “deficient” are defined as having levels at or below 20 ng/mL.

To make reading pleasant, I will mention more about MAO & COMT and the Urea Cycle in a following post…



By cbadmin