Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copied and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.
Pyrimidine Metabolites – Folate Metabolism
Remember this picture? This is from the series on MTHFR (methylation cycle).
The Pyrimidine metabolites in the Organic Acid test also point to your folate cycle. The important markers are Uracil and Thymine.
By methylation, uracil gets converted to thymine – one of the building blocks of DNA.
Results part 7
None of the markers raised any concerns.
Folate acts as a methyl donor in converting uracil to thymine.
Elevated Uracil could also indicate MTHFR homozygous gene mutation and methylation problems including high homocysteine. High levels of uracil are found with folate (vitamin B9) deficiencies because folate is needed to convert uracil to thymine by methylation.
High levels of thymine indicate a deficiency in vitamin B1. Low B1 is common among alcoholics, and people who are on a very high carbohydrate, low-nutrient diet. Very high levels are associated with inflammatory diseases and cancer.
This is why the MTHFR/ Methylation test and the Organic acid test go hand in hand.
According to some studies, around 10% of autistic children have elevated uracil acid. Great Plain Laboratories has a specific test testing Uric acids, click here.
*Sidenote*: Earlier blood tests (2016 and 2018) indicated that Alex has an issue with processing folic acid as you would get it from your multivitamins and supplements and your pregnancy supplement. Most doctors recommend women wanting to get pregnant and those who are pregnant take a folic acid supplement to prevent conditions like Spinal Bifida and cognitive disorders in their babies. However, if you have a genetic disposition to a reduced ability to process folic acid it can build up and cause more harm. That is why taking folinic acid or folate instead is more beneficial. Folinic acid and folate have already been through the methylation process to make are more useful to the body.
E-folate (RBS) 1305 (result) > 285 (range)(2016) / 2859 (result) > 500 (range)(2018)
Foods to eat that increase folinic acid or folate:
PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.
Updated on 30/09/2023 @ 18:59