Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copied and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.
Results Part 1
Most People on the Spectrum are said to have Yeast and Mould issues which present as gut issues.
In this section, the test looks at the markers for Mould (Aspergillus), Bacterial overgrowth, Fungal overgrowth, Yeast (candida) and Clostridia.
Labs comments: The microbial metabolic profile is suggestive of gut dysbiosis, primarily of yeast/fungal origin.
Dr Lindenberg’s comments: Mixed dysbiosis (imbalance) – bacterial and fungal: start treatment with Rifaximin and Fluzol and good probiotics.
1. Yeast
Candida albicans is the most common form of yeast in the body. Candida can build up toxins that contribute to fibromyalgia, migraines, chronic fatigue syndrome, brain fog, depression, and other symptoms.
In the Organic Acid test, Arabinose is normally an indicator for Candida. Tartaric Acid and 3-Oxoglutaric are also indicators of a candida infection. When Candida becomes invasive, it attaches to the intestinal wall causing a leaky gut. This can result in food sensitivities, nutrient malabsorption, and intestinal disorders.
2. Mould
5-Hydroxymethyl-2-Furoic (Sumiki’s acid) 8.9 (result) H / <1.7 (range)
A metabolite produced by Aspergillus and possibly other fungal species in the GI tract. Prescription or natural antifungals, along with high-potency multi-strain probiotics, may reduce overgrowth levels.
The Aspergillus, asparagus?… Aspergillus mould is the most common one found in the gut. The presence of Aspergillus indicates mould from food and water.
The markers for Aspergillus mould are 5-Hydroxymethyl-2-Furoic (Sumiki’s acid), Furan-2.5-dicarboxylic acid and N-2-Furancarbonylglycine.
These markers are important because Aspergillus produces a specific mycotoxin called aflatoxin which is a carcinogen. These mycotoxins are also damaging to the kidneys and liver. The presence of mould can suppress immune function in the gut increasing susceptibility to other microbial overgrowths.
You can read an interesting article about mould, click here.
3. Fungus
The Tricarballyllic acid maker is an indicator of a fungal infection. Overgrowths of yeast and fungi poison the mitochondria and contribute to mitochondrial dysfunction, stress hormone imbalances, and nutritional malabsorption.
4. Bacterial
4-Hydroxybenzoic acid 8.57 (result) H / < 3.6 (range)
2-Hydroxyphenylacetic Acid, 4 Hydroxybenzoic Acid, and 4-Hydroxyhippuric Acid and Hippuric acid are indicators of bacterial overgrowth in your gut and intestines.
Elevations in these markers are generally seen with gut dysbiosis and bacterial imbalances. 4-Hydrobenzoic acid is also an indication of eating too many jams and pie fillings containing parabens. 4-hydroxybenzoic acid can also increase after consuming almonds, strawberries, green tea, and ginkgo or oregano extract.
Parabens are a group of preservative ingredients used in cosmetics, personal hygiene products, food products and pharmaceuticals. They are highly effective in preventing the growth of fungi, bacteria and yeast that can cause products to spoil. Thus, they contribute directly to the quality of the products by extending their shelf life, making them safe for the families who use them.
Parabens are derived from para-hydroxybenzoic acid (PHBA) that occurs naturally in many fruits and vegetables, such as cucumbers, cherries, carrots, blueberries and onions. PHBA also is naturally formed in the human body by the breakdown of some amino acids.
For more about Parabens, click here.
Hurray for the Good Bacteria!
The biomarker DHPPA, 3.5 Dihydroxyphenolpropionic, shows how much good bacteria you have in your gut.
DHPPA in urine indicates intake of chlorogenic acid/ caffeic acid, a common substance in beverages and many fruits and vegetables. Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli increase the breakdown of chlorogenic acid to DHPPA so high values are mainly associated with increased amounts of these species in the GI tract. – from the Great Plains Labs breakdown Sheet
5. Clostridia
The toxins released by Clostridia metabolites can inhibit key neurotransmitters in the brain. Clostridia is associated with gastrointestinal disorders including irritable bowel syndrome, Crohn’s disease, and ulcerative colitis.
The most common clostridial infection is gastroenteritis (Clostridium perfringens food poisoning), a usually mild infection that typically resolves on its own.
If makers 4-Hydroxyphenylacetic, HPHPA and 4-Cresol are elevated then you have a Clostridia infection.
These markers can inhibit the enzyme dopamine beta-hydroxylase which can elevate dopamine and cause neurotransmitter imbalances. Both HPHPA and 4-Cresol are said to be higher in Autistic people, people with ADHD and other psychiatric disorders.
It is said that 4-Cresol feeds on Tyrosine, which is an important component in the production of neurotransmitters like dopamine, norepinephrine and epinephrine. Tyrosine also helps in the function of organs responsible for making and regulating hormones like the adrenal, thyroid and pituitary glands.
Other markers in the Microbiome:
- Indican (https://www.worldhealthlaboratories.com/indican) can increase on a diet high in protein and low in fibre. Vegetarians generally have lower indican levels. Indican levels also increase in malabsorptive disorders, such as celiac disease and hypochlorhydria (low stomach acid).
- Phenylacetic acid can increase with the ingestion of certain foods and drugs, exercise, gut dysbiosis, chronic alcoholism, and a metabolic disorder called phenylketonuria
- Phenylproprionate can increase in phenylketonuria
Causes for Yeast and Bacterial Overgrowth:
- Antibiotics
- Stress
- Diets, like the High Protein Diet, High Carbohydrate and sugar diets and diets high in Sulfates.
- Lowered immune system response
- Some medications, like antacids, antipsychotics, Metformin, opioids and Statins.
Terms: Dysbiosis – When the different species in our gut microbiota are no longer working together for mutual benefit, a condition called dysbiosis develops.
PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATING TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.
(updated 30/09/2023 @ 11:58)