MTHFR – Pyrrole Disorder

Please note: The content of this post is my own, unless the technical terms is too hard to explain, then the content is copy and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery. 

What is Pyrrole Disorder?

An inborn error of pyrrole chemistry which results in a dramatic deficiency of zinc and Vitamin B-6. Also known as Mauve Factor (due to the mauve color visible on testing paper during urinalysis) or pyrrole disorder, pyroluria occurs when the pyrroles bind to pyroxidine (vitamin B6) and zinc, causing these vital nutrients to be excreted from the body in large amounts.

Individuals with pyroluria exhibit a wide range of physical, emotional and cognitive symptoms; some common characteristics of pyrolurics are described here:

  • Schizophrenia;
  • ADHD
  • Autism;
  • Bipolar disorder;
  • Anxiety (including panic attacks);
  • Depression;
  • Alcoholism;
  • Poor dream recall;
  • Low tolerance for stress;
  • Antisocial behavior;
  • Behavioral problems (especially in children and teenagers) such as oppositional/defiant disorder;
  • Emotional instability, explosive temper;
  • Frequent joint pain;
  • Frequent infections;
  • Poor appetite, especially in the morning;
  • Low tolerance for protein – tend to favor vegetarian diets;
  • Pale complexion, inability to tan;
  • White flecks on the fingernails;
  • Nausea, motion sickness;
  • Hypoglycemia;
  • Allergies;
  • Fatigue
  • Crowded teeth and poor quality of the tooth enamel;
  • Retracted gums;
  • Sweet or fruity-smelling breath and sweat
  • sensitivity to light and sound

Treatment centers on normalizing blood levels of B-6 and zinc. Pyroluria supplements also contain several other nutrients in order to provide the most effective treatment:

  • Manganese: This vital nutrient is depleted when zinc is taken at the high levels necessary for treating pyroluria. Manganese is necessary for the metabolism of certain proteins; it is also important to joint development and neurotransmitter production.
  • Magnesium: Taking B6 in large amounts can deplete magnesium levels; adding magnesium can reduce irritability and hypersensitivity to light and sound.
  • Niacinamide (Vitamin B3): This nutrient is necessary for the production of tryptophan, which in turn is necessary for the production of serotonin. Taking niacinamide helps to speed the pyroluria recovery process.
  • Vitamin C and Pantothenic Acid: These nutrients help to rebuild adrenal glands that have been exhausted from coping with the ongoing tension caused by pyroluria; adding them to pyroluria supplements allows patients to overcome the weakness and fatigue they often feel.

You can learn a bit more about Pyrrole disorder here.

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