MTHFR Part 5: Trans-Sulfuration cycle – Vitamin B6

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copied and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science,…


Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copied and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Vitamin B6 (Pyridoxin)

The Trans-Sulfuration cycle is the Homocysteine process and this involves CBS and COMT.

The Homocysteine process happens when amino acids are broken down via the methionine process. The by-product is sulphur and ammonia. So once your folate cycle and methylation cycle are treated, your trans-sulfuration cycle will work properly.

Foods containing methionine are transformed into homocysteine in the bloodstream. Homocysteine is converted in the body to cysteine, with vitamin B6 facilitating this reaction. Homocysteine can also be recycled back into methionine using vitamin B12-related enzymes. Cysteine is a source of sulfide and is part of the metabolism of different metals in the body including iron, zinc and copper. Cysteine also acts as an antioxidant.

If homocysteine cannot be converted into cysteine or returned to the methionine form, levels of homocysteine in the body increase. Elevated homocysteine levels have been associated with heart attack, stroke, blood clot formation, and perhaps the development of Alzheimer’s disease.

This process is normally followed up with an Organic Acid Test, or you can also start with this test. (Homocysteine is tested on blood. Methyl malonate is the marker of vitamin B12 metabolism on the OAT)(amendment suggested by Dr Louise Lindenberg).

Vitamin B6 is also involved in the process of making serotonin and norepinephrine, which are chemicals that transmit signals in the brain.

As you all know from the previous post, Alex is already taking p5p (Pyridoxal-5-Phosphate) which is a form of B6, for small red blood cells.

PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.