My Colour is Blue

“Clear the Path, Fuel the Flow — Detox for Vital Balance.”

 

Your body has a natural detox system to get rid of harmful stuff, like chemicals or waste. A special group of helpers, called GST enzymes, play a big role in this process.

Here’s how it works:

1. When your body breaks down toxins (in a step called Phase I), it creates leftovers that can still be harmful.
   
   
2. The GST enzymes step in and attach a substance called glutathione to these leftovers. This makes them less harmful and easier to flush out of your body through things like sweat and urine.
   

Foods like broccoli, cabbage, garlic, and onions can help boost these enzymes, so eating them helps your body clean itself better.

Gene Name	Genetic Variation	Your Result	Gene Impact
CYP1A1	Msp1 T>C	TT	no impact
	Ile462Val A>G	AA	no impact
GSTM1	Insertion/Deletion	Deletion	Severe impact
GSTP1	313 A>G	GG	moderate impact
GSTT1	Insertion / Deletion	Insertion	no impact
NQ01	NQ01 C>T	TC	moderate impact

 

There are two Phases to Detoxification:

Phase 1

Phase 1 detoxification is the first step your body takes to clean out toxins—things like chemicals, drugs, or even by-products from food.

In this step, your liver uses enzymes to break down these toxins and turn them into smaller parts. But here’s the thing: after Phase 1, these broken-down parts can actually be more harmful than before if they’re not handled quickly.

That’s why your body needs Phase 2 right after, to safely package and remove them.

Think of Phase 1 like a factory that chops up trash—it makes it easier to throw away later, but it also makes a mess if the cleanup team (Phase 2) isn’t ready.

Alex’s Result: CYP1A1 Msp1 T>C / TT – no impact

The CYP1A1 gene gives instructions to make a special liver enzyme that helps your body process chemicals from the environment, like those found in pollution, cigarette smoke, or grilled meats.

Here’s what it does:

1. It turns some of these chemicals (called procarcinogens) into active forms—but these forms can sometimes damage cells and increase cancer risk if not cleared quickly.
   
2. It also helps break down oestrogens (hormones) in the body. If this process doesn’t work properly, it might raise the risk of hormone-related cancers like breast or prostate cancer.
   

So, CYP1A1 plays a double role: it helps clean out harmful substances, but if things go wrong, it could also raise the risk of cancer.

Alex’ Result: CYP1A1 Ile462Val A>G / AA – no impact

 

Phase 2

After Phase 1 breaks down toxins into smaller pieces (which can still be harmful), Phase 2 steps in like a cleanup crew.

In Phase 2, your body attaches special substances—like sulfur, amino acids, or glutathione—to those leftover toxins. This process makes the toxins safer and easier to flush out through urine, sweat, or poop.

So if Phase 1 is like chopping up trash, Phase 2 is like wrapping it up in bags and sending it out of your body.

To support Phase 2, your body needs good nutrition—especially protein, leafy greens, cruciferous veggies (like broccoli), and plenty of water.

 

Alex Result: GSTM1 Insertion/Deletion / Deletion

Glutathione S-transferase M1 (GST M1) is a special helper in your body that’s very good at clearing out harmful substances.

It works in the liver as part of Phase 2 detoxification, which is the part that packages toxins so they can be safely removed from your body.

GST M1 helps get rid of:

• Xenobiotics (chemicals from outside your body, like drugs or pollutants)
  
• Carcinogens (things that can cause cancer)
  
• Oxidative stress products (damaging substances made when your body is under stress)
  

Think of GST M1 as a powerful detoxifier that protects your body from damage by helping flush out the bad stuff.

If someone has a deletion in the GST M1 gene, it means their body doesn’t make that enzyme. Without it, the liver has a harder time removing harmful chemicals and waste, which can lead to a higher risk of health problems like:

• Certain types of cancer
  
  
• Chemical sensitivity (reacting strongly to smells or chemicals)
  
  
• Heart disease (especially in smokers)
  
  
• Asthma and breathing problems
  

To help protect the body, it’s recommended to:

1. Eat lots of antioxidants – These are nutrients that protect your cells. You find them in colourful fruits and vegetables.
   
2. Avoid toxins – Limit exposure to pollution, smoke, strong chemicals, and processed foods.
   
3. Eat more cruciferous vegetables like broccoli, cabbage, and kale, and allium vegetables like garlic, onions, and leeks – These can boost the activity of other detox enzymes that can help compensate.
   
4. If you’re not getting enough of these foods, a good-quality supplement with DIM (a compound from cruciferous veggies) might help.

 

Alex’s result: GSTP1 313 A>G / GG

Oxidative stress happens when there are too many harmful molecules (called free radicals) in the body and not enough protection to stop them. These molecules can damage your cells and increase the risk of many diseases.

The GSTP1 enzyme helps protect the body from this damage. It works by helping to neutralise harmful chemicals, especially in the lungs, where it’s found in large amounts.

If the GSTP1 enzyme isn’t working well, it may increase the chances of getting diseases that are linked to oxidative stress, like certain cancers or lung problems, and can also affect how these diseases progress over time.

In short: GSTP1 is like a protective filter, especially in the lungs, that helps remove dangerous substances before they cause harm.

The G allele is a version of a gene that can lower the activity of a specific enzyme, which helps the body detoxify. People with one G allele (like in the G/G genotype) have about 80% activity of this enzyme, and those with two G alleles (the GG genotype) have only 70% activity.

This means their body may not detoxify as effectively, which can increase the risk of damage from toxins.

To help boost enzyme activity, it’s helpful to eat more cruciferous vegetables (like broccoli, cabbage, and kale) and allium vegetables (like garlic, onions, and leeks). These foods help increase the activity of other detox enzymes in the body.

Eating these foods daily is recommended. If it’s hard to get enough through food, you might need a high-quality supplement with DIM, a compound from cruciferous vegetables that can help support detox.

 

Alex’s Result: GSTT1 Insertion / Deletion / Deletion – no impact

GSTT1 is a type of protein that plays an important role in detoxifying the body. It helps by attaching a substance called glutathione (a powerful antioxidant) to different harmful compounds—things that are electrophilic (reactive) or hydrophobic (repel water).

This attachment process is called conjugation, and it makes the harmful compounds easier to handle, break down, and remove from the body.

In simple terms: GSTT1 is like a helper that tags harmful substances with something safe (glutathione) so your body can get rid of them more easily.

 

Alex’s result: NQ01 NQ01 C>T / TC

NQO1, also called Quinone Reductase, is an important protein in your body that helps protect you from harmful substances.

• It works by detoxifying quinones, which are potentially dangerous chemicals that can come from things like tobacco smoke, certain foods, and even from how your body processes hormones like estrogen.
  
  
• NQO1 also protects cells from damage caused by oxidative stress (which is when there are too many harmful molecules in the body) by helping to keep antioxidants like ubiquinone and vitamin E in their active, protective form.
  

In simple terms: NQO1 is like a bodyguard that helps protect your cells from dangerous chemicals and oxidative damage, especially from things like smoking and hormone processing.

This is talking about a genetic change that affects a specific protein in your body. The change is a C-to-T switch (like changing one letter in a code), which leads to a change in the protein it produces. Instead of proline, the protein ends up with serine at a specific point (codon 187).

This change can make the protein less effective at doing its job, which is important for detoxifying harmful substances in the body.

• If you have one of these T alleles (the TC genotype), your enzyme’s activity is reduced by three times compared to people with the regular version (CC genotype).
  
• Having the TC genotype can increase your risk of developing certain cancers, like breast, colorectal, and gastrointestinal cancers, especially if you’re exposed to things like cigarette smoke.
  
• This genetic change has also been linked to higher toxicity from benzene (a harmful chemical).
  

In short: This genetic variation makes it harder for your body to handle toxins, which could increase the risk of cancer, especially when exposed to harmful things like smoke or chemicals.

Doctor’s recommendation:

• Follow-up test for Hepatic Detox Profile or Organic Acid test
• Increase fruit and vegetable intake, particularly cruciferous (Broccoli, Brussels sprouts, cabbage, cauliflower, kale, bok choy) and allium (garlic, onion, leeks, chives, scallions) vegetables.
• Supplements like DIM, Sulforaphane, resveratrol and curcumin.

Terms:

Insertion/ Deletion: Sometimes, a small change happens in a gene. Two common types are:

• An insertion means extra letters get added to the instructions.

• A deletion means some letters are missing from the instructions.

Even a tiny change, like one letter added or removed, can mess up the whole message, like a typo in a recipe. This can lead to a protein that doesn’t work the way it should, or doesn’t get made at all.

This is how insertions or deletions can sometimes affect health or increase the risk of certain conditions.

Want to find out more about Detoxification? Watch the video below:

PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.