My Colour is Blue

“Burn Smart, Build Strong — Mastering Life Through Lipid Metabolism.”

 

DNA Health

What is lipid metabolism?

Lipid metabolism is how your body uses and manages fats. Just like a car needs fuel to run, your body uses fats as one of its main energy sources, especially when you’re not eating (like during sleep) or doing long-lasting activities.

Step-by-step breakdown:

1. Eating Fats:
   When you eat foods like oils, butter, meat, or nuts, they contain fats—these are also called lipids.
   
2. Breaking Down Fats:
   Your body breaks these fats down in your digestive system into smaller parts called fatty acids and glycerol (like breaking logs into firewood).
   
3. Absorbing and Storing:
   These smaller pieces go into your bloodstream and are sent to places like your liver and fat cells.
   If your body doesn’t need the fat right away, it stores it for later, kind of like putting gas in a tank.
   
4. Using Fat for Energy:
   When you need energy (like when you’re walking, thinking, or sleeping), your body pulls fat out of storage, turns it into usable energy, and burns it to keep you going.
   
5. Balancing Act:
   Your body constantly balances how much fat it takes in, stores, and uses—sort of like managing a budget: spend some, save some.

Why It Matters:

• If everything works well, your body uses fat efficiently and keeps things in balance.
  
• If things go wrong (like eating too much fat or having a metabolic disorder), fats can build up in the blood or liver and cause health issues.)

Gene Name	Genetic Variation	Your Result	Gene Impact
LPL	1595 C>G	CC	No impact
CETP	279 G>A	AA	Beneficial
APOC3	3175 C>G	CC	no impact
APOE	E2/E3/E4	E3/E3	no impact
PON1	A>G	AA	no impact

Think of your bloodstream like a highway…

On this highway, you have different types of delivery trucks (lipoproteins) that carry cholesterol and fats around your body.

There are two main types of these trucks:

• HDL (High-Density Lipoprotein) – the “good cholesterol truck”
  
• LDL (Low-Density Lipoprotein) – the “bad cholesterol truck”
  

So, what does CETP do?

CETP is like a warehouse worker who helps transfer cargo between these trucks.

Specifically:

• CETP moves cholesterol (in the form of something called cholesteryl esters) from the good HDL trucks and loads it onto the bad LDL or VLDL trucks.
  
• In return, it moves some fat (triglycerides) back to the HDL trucks.

Why is this important?

• Too much CETP activity means more cholesterol gets taken away from the “good” trucks (HDL) and sent to the “bad” ones (LDL).
  
• This can lower your HDL (good cholesterol) and increase LDL, which might raise your risk of heart disease.
  

In simple terms:

CETP is like a swapper who moves cholesterol from the “good guys” to the “troublemakers.” Too much swapping can lead to problems.

LPL 1595 

What is Lipoprotein Lipase (LPL)?

Think of Lipoprotein Lipase as a pair of scissors sitting on the walls of your blood vessels (like little workers on the highway of your bloodstream).

What does it do?

When fat-carrying particles (called VLDL) travel in your blood, they’re like delivery trucks full of triglycerides (a type of fat).

LPL acts like those scissors and snips the fat (triglycerides) into smaller pieces, called free fatty acids, which your body can then use for energy or store as body fat.

Alex’s Result: 1595 C>G / CC

This small change can affect how well LPL works.

Why does that matter?

People with this genetic variant might:

• Store fat differently in their bodies
  
  
• Have different levels of fat in their blood
  
  
• Be more or less sensitive to insulin (a hormone that helps control blood sugar)

CETP 279 – CETP and Heart Health

• There’s a substance in your blood called CETP (Cholesteryl Ester Transfer Protein).
  
  
• When there’s too much CETP, it lowers your “good cholesterol” (HDL-C).
  

This is not good because low HDL means a higher risk of heart disease, especially coronary artery disease (CAD), which affects the heart’s blood supply.

Alex’s Results: CETP 279 G>A/ AA

The 279 A Allele – A Helpful Gene Variant

• Some people have a small natural change in their DNA called the 279 A allele.
  
• This change reduces the amount of CETP in their blood.
  
• That’s a good thing because it leads to:
  
  • Higher good cholesterol (HDL-C)
    
  • Lower risk of heart disease
    
• People with this A allele (genetic type GA or AA) benefit even more from a specific healthy diet:
  
  • High in alpha-linolenic acid (ALA) – a healthy plant fat found in things like flaxseeds, walnuts, and chia seeds
    
  • Low in cholesterol
    
• This diet helps lower the “bad” cholesterol types (VLDL-C and LDL-C), which also reduces heart disease risk.
  

So, if your body makes a lot of CETP, it can lower your good cholesterol and raise your risk of heart problems. But some people have a helpful gene (the 279 A allele) that keeps CETP levels low, protects their heart, and raises good cholesterol. Eating a healthy, plant-fat-rich, low-cholesterol diet can make these benefits even better for them.

People with a CTP 279 AA result do poorly on Statin-type medication.

APOC3 3175

Alex’s Results: ApoC3 3175 C>G/ CC

What is Apolipoprotein C3?

Apolipoprotein C3 (or ApoC3) is a small protein found in your blood that helps control how fats are processed in your body.

What does it do?

Think of fat particles in your blood like delivery trucks carrying fat (triglycerides).
To break down the fat and use it, your body uses special enzymes (helpers) called:

• Lipoprotein lipase
  
• Hepatic lipase
  

These are like scissors that cut the fat so your body can burn it for energy or store it.

But ApoC3 slows things down:

• ApoC3 blocks those scissors — it inhibits (stops or slows) both lipoprotein lipase and hepatic lipase.
  
• This means the fat in those delivery trucks sticks around longer in your blood.
  

So, Apolipoprotein C3 acts like a traffic cop that tells fat-cutting enzymes to slow down. As a result, fat stays in your bloodstream longer, which can lead to higher levels of cholesterol and triglycerides.

APOE E2/E3/E4

What is Apolipoprotein E (ApoE)?

Apolipoprotein E, or ApoE, is a helper protein in your body that plays an important role in how your body handles fats and cholesterol—kind of like a coordinator that helps fat-carrying particles go where they need to go.

What does it do?

• When your blood has triglyceride-rich particles (like delivery trucks full of fat), ApoE helps your body break them down and recycle them properly.
  
• Without ApoE doing its job, these fat particles can build up, which isn’t good for your heart and overall health.
  

What are SNPs and Allelic Isoforms?

Let’s break this part down:

• SNPs (single nucleotide polymorphisms) are tiny differences in your DNA, like small spelling changes in a recipe.
  
• These changes create 3 common versions (or “isoforms”) of the ApoE gene: E2, E3, and E4.
  
• Each version makes the protein a little different in shape (this is called protein conformation).
  

Why does that matter?

• The shape of the ApoE protein affects how well it can bind to receptors—these are like locks that help fat particles enter cells for breakdown or storage.
  
• Different versions of ApoE prefer different kinds of fat particles and have different strengths in doing their job.

Alex’s Reults: ApoE E2/E3/E4 – E3/E3

So, ApoE is a protein that helps your body process and clean up fat in the blood. Depending on your DNA, you might have a version of ApoE that works a little differently—some versions are better at handling fats than others, which can affect your heart and brain health.

PON1

What is PON1?

PON1 is a gene in your body that makes a special enzyme called paraoxonase. This enzyme acts like a protective cleaner for your cholesterol.

What does paraoxonase do?

You have two main types of cholesterol particles in your blood:

• LDL – often called the “bad” cholesterol
  
• HDL – the “good” cholesterol
  

These particles can get damaged by oxidation (similar to how metal rusts). When this happens, they become more likely to stick to artery walls, which can lead to heart disease.

Paraoxonase helps prevent this damage. It breaks down the harmful substances that cause oxidation, helping to keep LDL and HDL safe.

Why does this matter?

• If you have low levels of paraoxonase activity, your LDL and HDL aren’t well protected.
  
• That makes you more likely to develop clogged arteries, which increases your risk for coronary artery disease.

Alex’s Results: PoN1 A>G / AA

So, The PON1 gene makes a cleaning enzyme that protects your cholesterol from becoming harmful. If your body doesn’t make enough of this cleaner, your risk of heart disease goes up.

DNA Mind 

Alex’s Result: ApoE E2/E3/E4 – E3/E3

What is APOE?

APOE is a gene that gives instructions to make a protein called Apolipoprotein E (ApoE). ApoE is like a delivery truck that helps move fats and cholesterol around the body and brain.

What does ApoE do?

• It transports fats through your blood and into your brain.
  
• It helps with many important jobs, like cleaning up waste and keeping brain cells healthy.
  
• It’s also involved in processes that affect the development of Alzheimer’s disease (AD).
  

What are SNPs and Isoforms?

• SNPs are tiny changes in your DNA, like small typos.
  
• In the APOE gene, there are two key SNPs that lead to three versions (isoforms) of the ApoE protein:
  
  • ApoE2
    
  • ApoE3
    
  • ApoE4
    

Each version has a slightly different shape, which changes how well it works.

Why does this matter?

• The version of ApoE you have affects how well it binds to fats, connects to cell receptors, and interacts with amyloid-beta (Aβ)—a sticky substance in the brain linked to Alzheimer’s.
  
• For example, people with the ApoE4 version have a higher risk of developing Alzheimer’s disease, while ApoE2 may offer some protection.
  

So, The APOE gene makes a protein that helps move fats around your body and brain. Depending on your version of this gene, the protein works a bit differently, and that can affect your brain health and your risk for Alzheimer’s disease.

Alex’s Result: Carriers of the APOE E3/E3 genotype are considered to have the ‘neutral’ genotype, and are not associated with increased risk for cognitive decline. 

Recommendations:

• Manage Weight
• Excerise
• Balanced Healthy Diet

PLEASE NOTE: ANY VIEWS REGARDING THE RESULTS ARE MY UNDERSTANDING AND DO NOT SERVE AS PROFESSIONAL ADVICE. THE TREATMENT RECOMMENDATION IS STRICTLY RELATED TO ALEX’S RESULTS AND NOT MEANT FOR SELF-TREATMENT. ALWAYS SPEAK TO YOUR HEALTHCARE PROVIDER BEFORE STARTING ANY TREATMENTS.