Personalised Nutrition

The DNA Health report offers insights into how his genetics impact various health areas, including metabolism, detoxification, inflammation, vitamin processing, and his response to food. Here’s a simple summary of the most important findings and what they mean:

🔥 Priority Health Areas

The report highlights areas needing the most attention:

High Priority:
- Methylation – affects DNA repair, brain chemistry, and vitamin B handling.
- Detoxification – affects how well the body removes toxins.
- Oxidative Stress – influences the risk of chronic disease and inflammation.
- Insulin Sensitivity – relates to blood sugar regulation and risk for type 2 diabetes.
Moderate Priority:
- Inflammation
- Bone Health
Low Priority:
- Lipid Metabolism (Cholesterol and Fat Processing)

🧬 Key Genetic Results & What They Mean

1. Methylation

MTHFR 677 TT genotype: Reduced enzyme function (only ~40%) → increased need for folate, vitamin B2, B6, and B12.
MTHFD1 A allele: May increase choline needs.
COMT A allele: Reduced ability to clear certain hormones → may affect mood, estrogen metabolism, and stress resilience.

Action: Support with B-complex vitamins, choline-rich foods (like eggs), and magnesium.

2. Detoxification

GSTM1 – Deletion: Missing an important detox enzyme → reduced ability to clear toxins.
GSTP1 & NQ01 – Variants: Reduced enzyme efficiency.

Action: Eat cruciferous vegetables (broccoli, kale), alliums (garlic, onion), and consider DIM supplements if needed.

3. Oxidative Stress

Multiple genes (e.g., SOD2, GPX1) suggest a higher need for antioxidants.

Action: Focus on a diet high in vegetables, berries, selenium (e.g., brazil nuts), and avoid toxins, smoke, pesticides.

4. Insulin Sensitivity

Variants in FTO, TCF7L2, and PPARG suggest increased risk of insulin resistance and difficulty with blood sugar regulation.

Action:

Exercise regularly
Eat a low-GI, whole-food diet
Reduce sugar and unhealthy fat intake

🥗 Food Sensitivities & Nutrition Needs

Lactose Intolerance (CC genotype): Avoid dairy – may cause bloating and digestive issues.
Caffeine – Fast Metaboliser (AA): Can tolerate caffeine well.
Gluten Sensitivity (DQ2.2): Increased risk of celiac disease – may need further testing.
Vitamin D: Genetic variants indicate a higher risk of deficiency → Supplement and get sun exposure.
Vitamin A: May have reduced conversion from plant sources (like carrots) to active vitamin A → consider food sources of preformed vitamin A (e.g., liver, eggs).
Vitamin B12: Possible absorption issue → Ensure intake from meat/eggs or consider supplements.
Vitamin C: Active enzyme present, but with increased detox demands, intake should be adequate.

⚠️ Special Notes

Medium Taster (bitter foods): May dislike leafy greens → try seasoning or smoothies to boost veggie intake.
Iron Overload Risk: Mild form possible → consider testing iron levels; avoid excess vitamin C and iron supplements.

✅ What You Can Do:

Follow a nutrient-rich, whole-food diet with a focus on:
- Leafy greens
- Berries
- Cruciferous vegetables
- Choline-rich foods (eggs, salmon)
- Omega-3 fatty acids (flaxseed, walnuts, chia)
- Selenium (Brazil nuts)
Limit or avoid:
- Dairy (due to lactose intolerance)
- Processed sugar and saturated fats
- Environmental toxins (smoke, pesticides)
Supplement as needed (based on professional guidance) for:
- B-complex vitamins
- Folate (especially methylated forms)
- Vitamin D
- Possibly magnesium, choline, and vitamin A