All posts by cbadmin

Iris House

IRIS HOUSE Children’s Hospice

“We provide holistic, loving, professional, free community and Hospice based respite, overnight and end of life care for special needs children with life-threatening illness and or life-limiting conditions in the Western Cape. We also provide holistic support for their families.  We train our care team to a high standard and continually strive to train parents on ways to improve their child’s quality of life.  We promote the concept that every life is a gift and valuable no matter how short that life maybe.”

Visit Iris House and support a good cause.

Listen to some stories of the parents and staff of Iris House, click here.

 

Stimming

Stimming!

What is it and why do people do it?

This video says it all. Enough said.

Embrace Autistic Stimming | North Wales Autism Conference

This was my speech, "Embrace the Autistic Stim," at the 3rd Annual North Wales Autism Conference. It was such an honour and privilege to be invited to talk about autistic stimming, and the importance of self-regulation and freedom of movement.Sensory Warning: we recommend you listen to this on your speakers NOT headphones if you are auditory sensitive (like me)…the background noise is tinny and makes my teeth vibrate Huge thanks to Willow Caroline Holloway, Angie Atherton and Axia ASD for putting together such an amazing day.If you enjoyed this speech, please consider becoming an Agony Autie Donator by pledging on Patreon or making a contribution to our start up fund : https://www.facebook.com/donate/1764928653604665/

Posted by Agony Autie on Sunday, 21 October 2018

 

 

Levels of Autism

Levels of Autism

I have seen this statement a lot on some of the support pages I follow and heard the questions asked amongst parents:

“What level of Autism is your child?”

I almost want to say level 40, but I think it would just cause more confusion.

According to the article in the link below, there are three levels. The level of your child dependant on the amount of support your child needs with day-to-day tasks.

What are the three levels of autism?

There are also other labels like High or Low functioning – again, how much help does your child need with everyday tasks.

My advice: Focus on the strengths of your child and support the places where help is needed.

Organic Acid Test, Part 7: Amino Acid Metabolites

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Test results, part 4

Amino Acids

What is an amino acid, you ask? Amino acids are used in every cell of your body to build the proteins you need to survive. The best sources of essential amino acids are animal proteins like meat, eggs and poultry.

In the Great Plains Organic Acid test, there are about 15 markers that are tested for regarding amino acids. In the SA test, it is broken up into two categories.

Urine organic acids: Branched-chain amino acid intermediates

2-Ethylhydracrylic-/2-Ethyl-3-OH-propionic acid 0.35 < 2 mmol/mol creat
2-Hydroxyisocaproic acid 0.22 < 2 mmol/mol creat
2-Hydroxyisovaleric acid BDL < 2 mmol/mol creat
2-Oxoisovaleric acid / 3-Methyl-2-oxobutyric acid 0.22 < 1.1 mmol/mol creat
3-Hydroxy-2-methylbutyric acid 0.85 < 11 mmol/mol creat
3-Hydroxyisobutyric acid 5.48 L 20 – 118 mmol/mol creat
3-Hydroxyisovaleric acid 5.51 5.1 – 23.1 mmol/mol creat
3-Methyl-2-oxovaleric-/2-Keto-3-methylvaleric acid BDL < 4.8 mmol/mol creat
3-Methylglutaconic acid 2.89 < 20 mmol/mol creat
3-Methylglutaric acid 0.99 < 3.9 mmol/mol creat
4-Methyl-2-oxovaleric acid/2-Ketoisocaproic acid 0.16 < 0.86 mmol/mol creat
Malonic acid BDL < 5 mmol/mol creat

Urine organic acids: Other Amino acid intermediates

3-Hydroxyglutaric acid (Lysine Metabolism) 2.05 < 8 mmol/mol creat
Glutaconic acid (Lysine Metabolism) 0.58 < 3.1 mmol/mol creat
N-Acetylaspartic acid  (Aspartic Metabolism) 0.54 < 13 mmol/mol creat

This one is a bit more difficult to break down.

According to the Great Plains Lab break down:

2-Hydroxyisovaleric Acid

2-Oxoisovaleric Acid

3-Methyl-2-oxovaleric Acid

2-Hydroxyisocaproic Acid

2-Oxoisocaproic Acid

A moderate increase of branched-chain amino acid metabolites in urine may result from lactic acidosis, episodic ketosis, or deficiencies of the vitamins thiamine or lipoic acid.  Elevated 2hydroxyisocaproic acid in urine has also been linked to short bowel syndrome.  A significant increase of branched-chain amino acid metabolites is associated with the genetic disorders maple syrup urine disease (MSUD) or pyruvate dehydrogenase deficiency.  Patients with slight to moderate elevations may use dietary supplements containing thiamine to improve clinical symptoms.

2-Oxo-4-methiolbutyric Acid      Testing of plasma amino acids.        Elevated in an inborn error of methionine metabolism.  Confirmation of the genetic disorder requires

Malonic Acid Associated with the genetic disorders malonyl-CoA decarboxylase deficiency or malonic aciduria with normal malonyl-CoA decarboxylase activity.  Slightly elevated values in urine are unlikely to be clinically significant.

3-Methylglutaric Acid and 3-Methylglutaconic Significant increase are due to a reduced ability to metabolize the amino acid leucine.  This abnormality is found in the genetic disease methylglutaconic aciduria and in mitochondrial disorders.  3-Methylglutaconic acid may also be elevated.  Supplementation with coenzyme Q10, NAD+, L-carnitine and acetyl-L-carnitine, riboflavin, nicotinamide, biotin, and vitamin E may be useful.

Amongst the list were also markers found under Neurotransmitters which include Phenylalanine and Tyrosine Metabolites. But more about those in the next post.

So any reading in this section was the 3-Hydroxyisobutyric acid, which was low.

3-Hydroxyisobutyric acid (or 3-hydroxy-2-methylpropanoic acid) is an intermediate in the metabolism of Valine.

Data?1547234038
Just for fun: the chemical structure of 3-Hyrdoxyisobutyric acid

An interesting fact about Valine, it was first isolated from casein in 1901 by Hermann Emil Fisher. The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of the acid in the roots of the plant. Casein which is present in milk.

This result should be right because Alex does not drink milk or eat any dairy products, not because he is allergic to it or on a casein-free diet, but because he does not like it.

Dr Lindenberg comments: “Branched-chain amino acids OK with relatively low tyrosine metabolism.”

Interesting read: An Amino-Acid Deficiency That Causes Neurological Problems

There is a condition called 3-hydroxyisobutyric aciduria. In many affected people, the exact underlying cause of 3-hydroxyisobutyric aciduria is poorly understood. Scientists believe that some cases are caused by changes (mutations) in the ALDH6A1 gene. This gene encodes an enzyme called methylmalonate semialdehyde dehydrogenase, which helps the body break down certain amino acids (the building blocks of protein) found in food. If this gene isn’t working properly, the body is unable to break down the amino acids valine and thymine which leads to a build-up of toxic substances in the body and the many signs and symptoms of 3-hydroxyisobutyric aciduria. There is no cure for 3-hydroxyisobutyric aciduria. Because it is so rare, there is limited evidence to support the effectiveness of treatment. However, affected people have been treated with a protein-restricted diet and carnitine supplementation with varying degrees of success. (https://rarediseases.info.nih.gov/diseases/5662/3-hydroxyisobutyric-aciduria

 

Organic Acid Test: Part 6, Pyrimidine Metabolites

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Pyrimidine Metabolites – Folate Metabolism

Remember this picture? This is from the series on MTHFR (methylation cycle)

The Pyrimidine metabolites in the Organic Acid test also points to your folate cycle. In the Organic acid test, there are two acids they look for :

  1. Uracil
  2. Thymine

Folate acts as a methyl donor in converting uracil to thymine.

Elevated Uracil could also indicate MTHFR homozygous gene mutation and methylation problems including high homocysteine. High levels of uracil are found with folate (vitamin B9) deficiencies.

High levels of thymine indicate a deficiency in vitamin B1. Low B1 is common with alcoholics, and for people who are on very high carbohydrate, low-nutrient diet.  Very high levels are associated with inflammatory diseases and cancer.

This is why the MTHFR/ Methylation test and the Organic acid test goes hand in hand.

According to some studies, around 10% of autistic children have elevated uracil acid. Great Plain Laboratories has a specific test testing Uric acids, click here and here

From earlier blood tests (2016 and 2018) you can see that Alex has an issue with processing folic acid as you would get if from your multivitamins and supplements and your pregnancy supplement. Most doctors recommend women wanting to get pregnant and those that are pregnant to take a folic acid supplement to prevent this like spinal bifida and cognitive disorders in their babies, but if genetically you have a disposition to not be able to process that folic acid it can build up and cause more harm. That is why taking folinic acid or folate instead is more beneficial. Folinic acid and folate has already been through the methylation process to make are more useful to the body.

2016 vs 2018 Blood test – folic acid:
E-folaat (RBS) 1305 >285.0 2859 > 500

A slight increase, but apparently this is normal as your levels are not always the same every day.

Organic acid test results:
Thymine BDL < 0.8 mmol/mol creat
Uracil 0.71 < 6.8 mmol/mol creat

It was too low to measure. (I am yet to find a doctor to explain this to me – the reason why the blood test shows elevation and the organic acid test was too low).

Foods to eat that increase folinic acid or folate:

Another acid that is part of the methylation cycle and which is also picked up on the Organic acid test is Vitamin B12 or Methylmalonic Acid. But more about it later in the section on Nutritional Markers.

 

 

 

Organic Acid Test: Part 5, Ketones and Fatty Acids

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Test Results, Part 3

Urine organic acids: Fatty acid oxidation intermediates

3-Hydroxybutyric  acid BDL < 10 mmol/mol creat
Acetoacetic acid BDL < 24.9 mmol/mol creat
Adipic acid 9.43 < 37 mmol/mol creat
Ethylmalonic acid 3.49 < 17 mmol/mol creat
Methylsuccinic acid BDL < 6.05 mmol/mol creat
Sebacic acid 0.11 < 16 mmol/mol creat
Suberic acid 28.9 H < 20 mmol/mol creat

The markers measured here will show how well your body can process fat. These markers are sometimes elevated for persons on the Ketogenic diet or Low-carbs diet, but if there is an elevation in the results and a person is not on a Ketogenic diet it means that the body is not processing that fat too well.

If you are unable to process fat effectively your cells cannot put out the energy needed to function optimally.  Candida, bacterial toxins, and high oxalates can contribute to fat malabsorption. An anti-inflammatory nutrition plan is critical for improving these markers, along with targeted supplementation as indicated by other abnormal markers.

If you want to read more about Ketones, follow the link here.

Many people are following the Ketogenic diet, many dieticians or functional medicine practitioners have suggested the Ketogenic diet for Autistic people. Click here.

On the Great Plains lab results they list the following under Ketone and Fatty Acid Oxidation:

  1. 3-Hydroxybutyric Acid & Acetoacetic Acid
Ketones, such as 3-hydroxybutyric and acetoacetic acids, are the end-products of rapid or excessive fatty-acid breakdown.  Common causes of elevated ketones are prolonged fasting, protein malnutrition, high fat diet, vitamin B12 deficiency, severe GI Candida overgrowth, and pulmonary infections.  Dietary supplements containing L-carnitine or acetyl-L-carnitine may be beneficial.
2. 4-Hydroxybutyric Acid A moderate urinary increase in 4-hydroxybutyric acid may be due to intake of dietary supplements containing 4-hydroxybutyric acid, also known as gamma-hydroxybutyric acid.  Very high results may indicate the genetic disorder involving succinic semialdehyde dehydrogenase deficiency.

3. Adipic Acid Slightly elevated adipic acid may result from excessive ingestion of gelatin or other “junk” food containing adipic acid as an additive.  Elevated adipic acid may also indicate an abnormality in fatty acid metabolism.  Dietary supplements containing L-carnitine or L-acetyl-carnitine may be beneficial.  

4. Suberic Acid, Sebacic Acid, Ethylmalonic Acid & Methylsuccinic Acid Increased urinary products of omega- fatty acid metabolism pathway may be due to carnitine deficiency, fasting, or increased intake of triglycerides from coconut oil, or some infant formulas.  Very elevated values may indicate a genetic disorder.  Fatty acid oxidation defects are associated with hypoglycemia and lethargy.  Regardless of the cause, intake of dietary supplements containing L-carnitine, or acetyl-L-carnitine may improve clinical symptoms.

On Alex’s test, the Suberic Acid was elevated 28.9/ 20.  This is a very interesting acid, as it can indicate some-one was fasting overnight or AN INCREASE IN OIL USE.

The comments from the Lab technician stated: “The isolated increase in Suberic acid is likely dietary in origin and not suggestive of compromised beta-oxidation capacity.” 

The reason why I said that this result is interesting is that because we have been struggling with Alex to pick up weight, we started to give Alex food with a higher fat content like full cream yoghurt and using spread that 70% more fat spread than the more plastic margarine.  Also, and I know this is maybe THE reason why this acid is so elevated is that his chicken patties and french fries have been fried, even if it is only a little bit of oil, and not baked.

Organic Acid Test: part 4, Glycolytic Cycle and Krebs Cycle Metabolites

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Test Results, Part 2

In our South African test, the Glycolytic Cycle and Krebs Cycle results are combined, whereas in the Great Plains test it is separate.

Glycolysis is the metabolic pathway by which we convert glucose into lactate and pyruvate to form energy. If levels of lactic and pyruvic acids are elevated, a person has mitochondrial dysfunction.

High values for these markers may indicate that environmental toxins, particularly mold, are affecting your mitochondria. High lactic acid is commonly elevated with mold issues.

Glycolytic Cycle

Urine organic acids: Glycolysis and Krebs Cycle intermediates

2-Oxoglutaric acid/2-Ketoglutaric acid 1.72 L 36 – 103 mmol/mol
creat
Aconitic acid 24.67   17.3 – 63.3 mmol/mol
creat
Citric acid 31.44   < 656 mmol/mol
creat
D/L-2-Hydroxyglutaric acid 2.47   < 35 mmol/mol
creat
DL-Lactic acid 3.4 L 20 – 346 mmol/mol
creat
Fumaric acid BDL   2 – 42 mmol/mol
creat
Isocitric acid 12.97   < 99 mmol/mol
creat
Malic acid 0.13   < 73 mmol/mol
creat
Pyruvic acid 0.05   < 19 mmol/mol
creat
Succinic acid 10.09 L 16 – 156 mmol/mol
creat

In the Glycolytic we look at the following markers

  1. Lactic acidLactic acid is produced as part of the cycle when your body takes food, or sugars, and process it for energy. You know that burn you feel in your muscles after some exercises, that is lactic acidosis. In Afrikaans, we speak of “miltsteek”, that sharp pain you somethings get in your side after exercising especially when you are unfit. Elevations of lactic acid and/or pyruvic acid can also be caused by many nonspecific factors, such as vigorous exercise, bacterial overgrowth, shock, anaemia, mitochondrial dysfunction, or other causes.
  2. Pyruvic acid – Pyruvic acid can be made from glucose (sugar) through glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or to fatty acids through a reaction with acetyl-CoA.
  3. 2-Hydroxybutyric acid – 2-Hydroxybutyric acid is a ketone body produced as a by-product of fatty acids oxidation for energy. This acid will be elevated if there is a yeast overgrowth.

Elevated levels of these three acids might indicate there are inborn errors of metabolism, including disorders of sugar metabolism and pyruvate dehydrogenase deficiency. The possibility of an inborn error of metabolism increases as the lactic acid value exceeds 300 mmol/mol creatinine and when pyruvic acid exceeds 100 mmol/mol creatinine.

Krebs Cycle

For more details on the Krebs Cycle, you can read more about it as part of the MTHFR series, click here.

Like previously mentioned the Glycolytic Cycle and the Krebs cycle is actually part of the same process. The Krebs cycle uses sugars to create lactic acid and pyruvic acid to produce energy for the cells.

In the Krebs Cycle they look at these markers:

  1. SuccinicLow levels could indicate a need for the branch chain amino acids leucine and isoleucine. An elevated result may also indicate a relative deficiency of riboflavin and/or coenzyme Q10.  Suggest supplementation with a minimum of 20 mg riboflavin and/or 50 mg per day of coenzyme Q10.  Also produced by bacterial degradation of unabsorbed glutamine supplement. Foods that contains Succinic acid include broccoli, rhubarb, sugar beets, fresh meat extracts, various cheeses, and sauerkraut.  
  2. Fumaric (Increased urinary fumaric acid may be due to impaired Krebs cycle function, a defect in the enzyme fumarase or in mitochondrial function.)
  3. Malic (Slightly elevated values usually indicate a higher need for nutrients such as niacin and coenzyme Q10.When malic acid is simultaneously elevated with citric, fumaric and 2-ketoglutaric acids, a mitochondrial energy pathway dysfunction is strongly suggested.)
  4. Citric (Elevations may be due to increased intake of citric acid containing foods or result from intestinal yeast producing citric acid or perhaps inhibiting the human citric acid cycle.  Increased citric acid may also indicate depletion of glutathione, which is required for the enzyme aconitase to metabolize both aconitic and citric acids.  If pyroglutamic acid values are low, consider supplements containing glutathione, n-acetyl cysteine, or lipoic acid.)
  5. 2-Ketoglutaric acids/ 2-Oxoglutaric acid – Increased values in urine may be due to dietary vitamin deficiencies or the intake of 2-ketoglutaric acid as a supplement.  The conversion of 2-oxoglutaric acid to succinyl-CoA requires coenzyme A (derived from pantothenic acid), lipoic acid, flavin adenine dinucleotide (FAD) derived from riboflavin (B2), and thiamine (B3).
  6. Aconitic Acid (Aconitase, the enzyme that metabolizes citric and aconitic acids, is dependent upon glutathione. Elevated in mitochondrial disorders (e.g. Complex I and Pierson Syndrome).  Elevated aconitic acid may indicate an additional requirement for reduced glutathione.)

Elevations in Krebs Cycle metabolites are commonly due to environmental toxins such as heavy metals or mold, yeast/fungal or bacterial overgrowth, high oxalate levels, or high oxidative stress. A less common indication of high levels would be a genetic issue.

Organic Acid Test: Part 3, Oxalate Metabolites

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Oxalate Metabolites

 

Oxalic acid is one of the most acidic organic acids in bodily fluids. This organic acid is derived primarily from fungus (Aspergillus and Penicillium), Candida, or your metabolism. Excessive consumption of high oxalate foods and deficiencies in vitamin B6 can contribute to elevations in oxalic acid.

Many of the foods very high in oxalates are healthy foods. High oxalate foods include spinach, beets, chocolate, peanuts, wheat bran, tea, berries, and nuts (cashews, pecans, and almonds).

Testing oxalate levels are important because high oxalates can be very dangerous. Oxalate crystals have a sharp physical structure that can cause oxidative damage, increase inflammation, cause pain, and damage tissues.

Oxalate crystals may form in joints, blood vessels, muscles, kidneys, lungs, heart, thyroid, eyes, and even the brain. High oxalic acid can hinder the proper function of vital bodily functions, poison the mitochondria, and contribute to kidney stones.

High oxalates in the GI tract may significantly reduce the absorption of essential minerals such as calcium, magnesium, zinc, and more. Oxalates may form in the bones, crowding out bone marrow cells. This can lead to anaemia and immunosuppression. Identifying elevated oxalate metabolites is significant for people with chronic pain, joint issues, kidney stones, and other health issues.

Organic Acid Test: Part 2, Intestinal Microbiomes

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

Results part 1 – Intestinal Microbiome

The test was done by my son’s specialist through North West University.

Urine organic acids: Micobiome markers

2,5-Furandicarboxylic acid 5.17 < 12 mmol/mol creat
2-Hydroxyphenylacetic acid 0.68 < 20 mmol/mol creat
3,4-Dihydroxyphenylpropionic acid 0.11 < 0.35 mmol/mol creat
3,5-Dihydroxyphenylpropionoic acid (DHPPA) 0.04 < 0.38 mmol/mol creat
3-Hydroxyphenyl-3-hydroxypropionic acid  (HPHPA) 1.81 < 91.5 mmol/mol creat
3-Indoleacetic acid 4.28 < 12.3 mmol/mol creat
3-Oxoglutaric acid/3-Ketoglutaric acid BDL < 0.46 mmol/mol creat
4-Hydroxybenzoic acid 8.57 H < 3.6 mmol/mol creat
4-Hydroxyhippuric acid 7.76 < 14 mmol/mol creat
4-Hydroxyphenylacetic acid 21.93 9.7 – 187.4 mmol/mol creat
5-Hydroxymethyl-2-furoic acid (Sumiki’s acid) 8.09 H < 1.7 mmol/mol creat
Arabinose 4.28 < 19.4 mmol/mol creat

The Microbiome makers look for:

  1. Yeast (Candida)
  2. Mould (Aspergillus)
  3. Fungus
  4. Bacterial
  5. Clostridia
Yeast

Candida albicans is the most common form of yeast in the body. Candida can build up toxins that contribute to fibromyalgia, migraines, chronic fatigue syndrome, brain fog, depression, and other symptoms.

In the Organic Acid test, Arabinose is normally an indicator for Candida. Tartaric Acid and 3-Oxoglutaric are also indicators of a candida infection.   When Candida becomes invasive, it attaches to the intestinal wall causing leaky gut. This can result in food sensitivities, nutrient malabsorption, and intestinal disorders.

(As from Great Plains Clinical break down sheet:

Arabinose  Produced by the action of Candida hyaluronidase on the intercellular cement hyaluronic acid.  Oxidation of the hyaluronic acid breakdown products produces tartaric acid and arabinose.  Since arabinose is also a major sugar in apples, grapes, and pears, these fruits and their products must be avoided 24 hours prior to urine collection to avoid interference.  Antifungal treatment and high-potency multi-strain probiotics may help rebalance GI flora.

Tartaric Acid Produced by the action of Candida hyaluronidase on the intercellular cement hyaluronic acid. Oxidation of the hyaluronic acid breakdown products produces tartaric acid and arabinose.  Since grapes, grape juice, and dried grapes (raisins) contain tartaric acid, these foods must be avoided 24 hours prior to urine collection to avoid interference.  Antifungal treatment and high-potency multi-strain probiotics may help rebalance GI flora. 

3-Oxoglutaric Acid Indicates a possible yeast overgrowth in the GI tract.  High-potency multi-strain probiotics may help rebalance GI flora.)

Clostridia

The toxins released by Clostridia metabolites can inhibit key neurotransmitters in the brain. Clostridia is associated with gastrointestinal disorders including irritable bowel syndrome, Crohn’s disease, and ulcerative colitis.

The most common clostridial infection is gastroenteritis (Clostridium perfringens food poisoning), a usually mild infection that typically resolves on its own.

If makers 4-Hydroxyphenylacetic, HPHPA and 4-Cresol is elevated then you have a Clostridia infection.

These markers can inhibit the enzyme dopamine beta-hydroxylase which can elevate dopamine and cause neurotransmitter imbalances. Both HPHPA and 4-Cresol are said to be higher in Autistic, people with ADHD and other psychiatric disorders.

It is said that 4-Cresol feeds on Tyrosine.

(As from the Great Plains Lab clinical breakdown sheet:

4-Hydroxyphenylacetic A tyrosine metabolic product of GI bacteria.  Elevated levels are associated with bacterial overgrowth or small bowel disease.  May also indicate celiac disease.

HPHPA An abnormal phenylalanine metabolite produced by gastrointestinal bacteria of Clostridia species, including sporogenes, botulinum, caloritolerans, mangenoti, ghoni, bifermentans, difficile, and   sordellii.  Negative stool tests for C.difficile do not rule out the presence of other Clostridia species.  This metabolite may is frequently associated with behavioural and neurological abnormalities that resolve after antimicrobial therapy.  In many cases, Clostridia overgrowth can be controlled by supplementation with 30 billion cells per day of Lactobacillus rhamnosus GG (Culturelle) and/or 2-6 billion cfu’s of Saccharomyces boulardii.   

4-Cresol Indicates a possible overgrowth of intestinal bacteria that are specific p-cresol producers including 4-Cresol is a phenolic product poorly metabolized in children with autism.  High-potency multi-strain probiotics may help rebalance GI flora.)

Fungus

The Tricarballyllic acid maker is an indicator of a fungal infection. Overgrowths of yeast and fungi poison the mitochondria and contribute to mitochondrial dysfunction, stress hormone imbalances, and nutritional malabsorption.

(As from the Great Plains Lab breakdown sheet:

Tricarballyllic Acid A chemical by-product released from fumonisins during passage through the gastrointestinal tract. Fumonisins are fungal toxins produced primarily by F. verticillioides.  Elevated levels can be caused by the intake of corn or corn-based food contaminated with fumonisins. )

Good Bacteria

The biomarker DHPPA shows how much good bacteria you have in your gut.

(As from the Great Plains Labs breakdown Sheet:

DHPPA  DHPPA in urine indicates intake of chlorogenic acid, a common substance in beverages and many fruits and vegetables.  Harmless or beneficial bacteria such as Lactobacilli, Bifidobacteria, and E. coli increase the breakdown of chlorogenic acid to DHPPA so high values are mainly associated with increased amounts of these species in the GI tract.)

The only two markers left is the Mold and the Bacterial, those were the ones that were most elevated on Alex’s test.

Mold

The Aspergillus mold is the most common one found in the gut. The presence of Aspergillus indicates mold from food and water.

The markers for mold is 5-Hydroxymethyl-2-Furoic (Sumiki’s acid), Furan-2.5-dicarboxylic acid and N-2-Furancarbonylglycine:

5-Hydroxymethyl-2-Furoic (Sumiki’s acid)            8.9 H / <1.7

These markers are important because Aspergillus produces a specific mycotoxin called aflatoxin which is a carcinogen. These mycotoxins are also damaging to the kidneys and liver. The presence of mold can suppress immune function in the gut increasing susceptibility to other microbial overgrowths.

(As per the Great Plains Labs breakdown sheet:

5-Hydroxymethyl-2-Furoic (Sumiki’s acid) A metabolite produced by Aspergillus and possibly other fungal species in the GI tract.  Prescription or natural antifungals, along with high potency multi-strain probiotics, may reduce overgrowth levels. 

Furan-2.5-dicarboxylic acid A metabolite produced by Aspergillus and possibly other fungal species in the GI tract.  Prescription or natural antifungals, along with high potency multi-strain probiotics, may reduce overgrowth levels. 

N-2-Furancarbonylglycine A metabolite natural antifungals, along with high potency multi-strain probiotics, may reduce overgrowth. produced by Aspergillus and possibly other fungal species in the GI tract.)

You can read an interesting article about mold from Dr Jockers – Mold Exposure: Signs of Mold growth & health risks

Bacterial

2-Hydroxyphenylacetic Acid, 4 Hydroxybenzoic Acid, and 4-Hydroxyhippuric Acid and Hippuric acid are indicators of bacterial overgrowth in your gut and intestines.

4-Hydroxybenzoic acid                                               8.57 H / < 3.6

Elevations in these markers are generally seen with gut dysbiosis and bacterial imbalances. 4-Hydrobenzoic acid is also an indication of eating too many jams and pie fillings containing paraben preservatives.

Parabens are derived from para-hydroxybenzoic acid (PHBA) that occurs naturally in many fruits and vegetables, such as cucumbers, cherries, carrots, blueberries and onions. PHBA also is naturally formed in the human body by the breakdown of some amino acids.

For more about Parabens, click here.

(As per the Great Plains Labs breakdown sheet:

2-Hydroxyphenylacetic Acid Elevated 2-hydroxyphenylacetic acid is associated with intestinal bacteria overgrowth.  High-potency multi-strain probiotics may help rebalance GI flora. 

4 Hydroxybenzoic Acid A marker for intestinal dysbiosis. The use of probiotics and the exclusion of paraben-containing foods is the first treatment consideration.

4-Hydroxyhippuric Acid A glycine conjugate of 4-hydroxybenzoic acid, a metabolite of paraben preservatives.  May be elevated after exposure to paraben antimicrobials in certain foods and cosmetics.  Intake of fruits containing polyphenols rich in anthocyanins, flavonols, and hydroxycinnamates may increase this compound in the urine.  Avoid exposure to parabens.   

Hippuric acid A bacterial product of phenylalanine metabolism.  Most hippuric acid in urine is derived from the microbial breakdown of chlorogenic acid, a common substance found in beverages and in many fruits and vegetables.  Higher levels indicate GI bacterial overgrowth that can be reduced with natural antibacterial agents and/or high-potency multi-strain probiotics.)

Labs comments: The microbial metabolic profile is suggestive of gut dysbiosis, primarily of yeast/fungal origin. 

Dr Lindenberg’s comments: Mixed dysbiosis (imbalance) – bacterial and fungal: start treatment with Rifaximin and Fluzol and good probiotics

Organic Acids Test: part 1, Introduction

Please note: The content of this post is my own unless the technical terms are too hard to explain, then the content is copy and paste. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.

What is It?

The Organic Acids Test (OAT) is a comprehensive test that gives metabolic insight into a person’s overall health. Some of the markers on the organic acids test including vitamins and antioxidants, oxidative stress, energy production, detoxification, neurotransmitter levels, oxalates, and intestinal yeast and bacteria.

It is believed that people with chronic illnesses, neurological issues, and other health conditions often excrete abnormal acids in their urine.

Organic Acids Test

What does it all look at?

The OAT looks at complex biomarkers from various metabolic pathways.

Abnormal concentrations of organic acids provide functional markers for the metabolic effects of micronutrient inadequacies, toxin exposure, neuroendocrine activity, enzyme deficiencies, and intestinal bacterial overgrowth.

The OAT gives an overview of several major systems in the body and analyzes nutrient deficiencies. Utilizing this test can reveal the need for dietary modifications, antioxidant and nutrient support, detoxification, oxalate reduction, and other therapies.

As you can see there is also a lot of sections that the Methylation Test also tests for, but the organic acid test tells you in the pathways is missing.

Next, we will look at who to review a test through Alex’s results.

pictures from Dr Jockers.com