MTHFR part 12: CBS part 4

Lets talk Elements…


If you have a CBS mutation, keeping an eye on your hormones is important as well as maintaining minerals like Copper, Molybdenum, Zinc and Manganese.

A possible consequence of CBS upregulation is and increase in Copper (read about copper overload here.)

Other serious health conditions due to a CBS irregularity is:

  • Blood – iron deficiency anemia
  • Liver impairment – Wilson’s disease
  • Immune system – prolonged viral and fungal infections, delayed wound healing
  • Thyroid gland – thyroid insufficiency and hypothyroidism
  • Nervous system – depression, anxiety, and aggression
  • Neurological disorders – some emotional disorders, impaired mental function
  • Reproductive hormonal imbalances – PMS
  • Adrenal gland – adrenal fatigue, insufficiency, and weakness
  • Gastrointestinal disorders – constipation and gastritis
  • Musculoskeletal system – scoliosis, osteoarthritis, or poor collagen and elastin production
  • Cholesterol – hypercholesterolemia, or high cholesterol levels in the blood
  • Gallbladder – gallstone formations

Low zinc level can lead to issues with loss of appetite, taste and smell, frequent infections, elasticity of skin, low fertility, or pale, acne prone skin.

  • Possible low homocysteine levels.
  • Sleep problems.
  • Oxidative stress.
  • Stomach issues.
  • Dizziness and low blood pressure due to increased hydrogen sulfide.
  • Possible high blood pressure from changes in lower homocysteine levels.
  • BH4 deficiency can cause depression, anxiety, mood problems, or panic attacks.

Molybdenum deficiencies could cause breathing difficulties or neurological disorders.

  • A deficiency of Vitamin B1 can lead to a multitude of disorders including tender muscles, rapid heartbeat, poor memory, irritability, and constipation.
  • Low levels of Vitamin B2 can cause split nails, skin problems such as cracked lips, dull or oily hair, and eczema, as well as problems with eyes including burning sensations, cataracts, and sensitivity to bright lights.
  • Vitamin B6 deficiencies are often responsible for water retention, tingling hands, depression, infrequent dream recall, nervousness, irritability, lack of energy, flaky skin, muscle tremors, and cramps.

So, CBS is just as important as the Folate Cycle.  Functions in both the Folate cycle and CBS happens at the same time, yet they can function independently.


MTHFR part 11: CBS part 3

Please note: The content of this post is my own, unless the technical terms is too hard to explain, then the content is copy and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery. Always consult your doctor first before trying a new treatment.

Leaky bucket / Food sensitivities

If your CBS cycle is not working properly, think about it as you having a leaky bucket.

Everything you place into the bucket just leaks in to your liver and kidneys to be filtered. But because of the holes in your bucket nothing get filtered properly and this can lead to nutrients, minerals and antioxidant deficiencies. We the reduction in nutrients being absorb, food sensitivities can occur. This can result in leaky gut syndrome and increased issues with your gut.

An CBS issue is responsible for the evelvation of Taurine, ammonia, sulfites and hydrogen sulfide.

An CBS mutation can be a bugger, because no matter how much you change your diet, try to live health and take supplements, the mutation can cause your “good living” to be bad for you. this process can also raise the levels of glutamate which can lead to excitotoxicity.

We know that the gut is involved too, and with the gut working with the adrenal glands, any issues with constantly stimulate the body’s fight or flight system. And with the body being swamped with the gut-based molecules such as high amounts of folic acid/folate created by the CBS upregulation, potent toxins can upset the methylation cycle. This can cause a condition called Adrenal Fatigue Syndrom.

(no wonder doctors always treat autistic people for anxiety, because they are always in a constant fight/flight mode – always anxious)

In men a CBS mutation can also cause issue with their testosterone.


MTHFR part 10: CBS, the Liver Pathway continues…

Please note: The content of this post is my own, unless the technical terms is too hard to explain, then the content is copy and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery. Always consult your doctor first before trying a new treatment.

… So the CBS gene helps the liver to detox the body

Remember the BH4 (Better for Health) in the Folate Cycle? It has also been observed that BH4 (assistant in making serotonin, dopamine, thyroid hormones, and melanin), can also become depleted if CBS is not working properly. BH4 is extremely, important as it helps regulate neurotransmitters and mood. Other gene mutations, such as MTHFR A1298C, chronic bacterial infections, and aluminum, can also lead to low BH4 levels. It is important to maintain an accurate level of BH4 in the body as a lack thereof can lead to mast cell degranulation or mast cell activation disorder (MCAD). CBS upregulation substantially upsets the urea cycle. This enzyme depletes the BH4 enzyme while overloading the urea cycle.

Thus, because CBS connect with the BH4, and if the detox process is not working properly and there is a high amount of ammonia build up, aggressive or sedated behavior after consuming foods with L-glutamine can occur. Therefore it is recommended to lower the sulfur rich food in your diet to prevent extra stress on your system.

Most foods has sulfur in, the key is MODERATION. make sure your CBS is functioning properly and eat sulfur rich food in moderation, even the beloved kale everyone is raving about.

Together with the sulfur, you also need to look at thiol. When food contain high thiols it can also increase the sulfur in the foods. It is also what gives the skunk it stink and onions its smell.

However, also look out for products that contain:

  • Sodium sulfite
  • Sodium bisulfite
  • Sodium metabisulfite
  • Potassium bisulfite
  • Potassium metabisulfite
  • Sulfur dioxide

as they can cause allergic reactions.

For more details on Sulfur related allergies, you can click here.



MTHFR part 9: Methionine Cycle – CBS

Please note: The content of this post is my own, unless the technical terms is too hard to explain, then the content is copy and pasted. I am not a medical professional and thus the post is my point of view. But the content is science-based and credible. Just because it is a new science, does not necessarily make it quackery.  

CBS: The direct path to the liver

CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.

In order for the conversion from Homocysteine to Cystathionine to run smoothly you will need the Vitamin B6. If your levels are low or too high your CBS process does not function properly.

Cysteine is a precursor to glutathione, while methionine is important for DNA methylation and the growth of new blood vessels.

Glutathione is required for many processes, including immune function, detoxification, and the function of other antioxidants. Glutathione is a peptide that is produced through biosynthesis of three non-essential amino acids: cysteine, glutamate, and glycine. The highest concentrations are found in the spleen, liver, pancreas, and cornea.

As a powerful antioxidant, glutathione prevents damage to cells by neutralizing free radicals and detoxifying heavy metals. Without the protective actions of glutathione, free radicals and toxins begin to accumulate in the body causing oxidative stress to cells resulting in overall congestion of the body and a sluggish detoxification system. Adrenal Fatigue Syndrome is often an indication of low glutathione.

If you have been lacking in glutathione for an extended period of time (months or even years), there is a chance that your body has accumulated high levels of mercury. And we all know mercury in the body is not good.

Researchers found that a disruption of the normal function of CBS causes a buildup of homocysteine and other toxins in the blood. This causes nutrients to enter and leave the body, without any absorption. A buildup of homocysteine and other toxins can cause a buildup of plaque in the blood vessels leading to Cardio-vascular conditions.

Issues with the CBS gene can cause homocystinuria, an inherited disorder that keeps the body from processing the essential amino acid methionine…

Follow on a previous post about picky eaters

This question was asked on an Autism Facebook group:

Q: Anyone else have issues with getting their kids to try new foods?
My son has such a limited range of foods that he will eat. We have been trying for two years to get him interested in veggies, meat, rice and pasta other than 2-minute-noodles. We have tried everything they say you must do: “smell, and one bite”, bite and spit out, try a food for 20 days, stop for 20 days then try again, eating together, eating together at a table, eating without the TV, eating while watching his favourite program, and even have his teacher at the day care try. We have involved him inbthe cooking process to, he will make the food but not eat it.Nothing has worked. He eat mixed textures, so it is not textures. There is no medical issue, he does not gag when he eats. Supper takes almost 2 hours to complete, sometimes we just give up. Sometimes he will eat, play and come back to his food. But dispute being on a limited diet and just above the underweight line he is healthy. But he has very little fat around his important organs, which is not good should he ever get injured.
Any suggestions?

A:  If you’ll allow me, I’d like to help you understand your son’s food aversions better, as an autistic adult who has major sensory issues, because I know that it’s probably incredibly difficult for you to comprehend how things that seem utterly benign to you can be SO PROBLEMATIC for him.

The best analogy I can give you with food is the one I gave the dental hygienist a few months ago when he wanted me to rinse with a blue anti-bacterial solution and I said no. He insisted, and assured me that it didn’t taste bad, and I refused again and explained about my sensory issues. “But it’s just for a moment and then you spit it out,” he said. And that’s when I started to cry.

Because you see, when I looked at that solution, my BRAIN said, “That is NOT FOR HUMAN CONSUMPTION.” I apologize for this extreme wording, but . . . the hygienist might as well have been asking me to sip on a cup of urine. And that is how your son feels when he looks at foods that he cannot eat. His BRAIN is telling him, “Those things are NOT FOR EATING.” They might as well be . . . well, poop. And so it doesn’t matter if Mum and Dad say, “But they’re lovely, and they taste nice, and they are completely healthy and good for you.” Because, not to put too fine a point on it, but . . . if you looked at what was CLEARLY a poop sandwich and someone told you it was lovely and healthy, would that make YOU want to eat it any more than you already did? Probably not. Your brain would STILL be telling you: “NOT FOR EATING!!” with big flashing lights, no matter what they said.

And this is what parents need to understand about autistic kids with sensory issues around food. They are NOT “picky eaters”. They have brains that are showing them something COMPLETELY DIFFERENT from what you are seeing, and it is actually cruel to force them to eat these foods if they’re telling you that they can’t. And yes, we are painfully aware that this can lead to nutritional deficits and gastrointestinal problems–most of us have had both at some point or another throughout our lives. Which is why it is a struggle, and it DEFINITELY is a good idea to talk to your kids about what flavours and textures they DO like (crunchy? soft? bland? tart? sweet?) and try to work within those to introduce what variety you can, and talk to their paediatrician to make sure they’re getting a multivitamin and possibly others to supplement if necessary. It’s awful and definitely NOT the ideal . . . but neither is traumatizing them over food, because the OTHER really common thing in autistic adults is lifelong eating disorders over having been made to eat things we couldn’t cope with.

 Q: I just need to understand, and I am sorry if thing sound blunt or disrespectful, how do you go from eating everything to “I cannot eat this”. When you have had a previous experience with the food item, you know how it tastes and smells and feels and you liked it – all of a sudden it is like you have never eaten it before and not going to try it. What causes that switch?

A: It’s an excellent question! I wish I had a better answer, but I’m guessing that it has to do with the neurological aspect of autism, and the fact that these things are literally “chemical” and filtered through our brain’s synapses–as opposed to being “psychological” like a behaviour.

To be more clear: I think what you’re looking at is the rare, but not completely inexplicable opposite of when a persons brain learns to “get used to something new”; which is that some weird chemical or synaptic switch has flipped in their brain that is suddenly telling them that this smells bad or tastes funny when it didn’t previously . . . but it IS an actual SENSORY PERCEPTION rather than just a behavioural decision.

Again, an example of this happening is that I started a new medication a while ago for my migraines, and it actually affects the chemical makeup of my blood in a manner similar to chemotherapy. My doctor didn’t warn me about this, but suddenly all kinds of foods started to taste bad!! I thought there was something wrong with my tastebuds! Things that I loved–chocolate, Coke, ice cream–suddenly tasted weird and terrible! It turned out that it wasn’t my tastebuds, it was literally a side effect of the medicine and my blood chemistry!! It has totally changed the way I eat (and I still don’t like Coke anymore, LOL).

In your son’s case, I’m assuming he’s not on any new meds, but over time sometimes things just change. Just like you learn to like different foods as you grow up, unfortunately, he may come to dislike some as well–a smell may start to seem unpleasant to him, or a texture, for no real reason except that his body is changing and growing and his brain is doing the same. Sometimes this can work in your favour (I had a sweet tooth as a young child, but by the time I was 5 would have a meltdown if someone even ate a hard candy near me, I was so sensitive to the smell of artificial flavours).

The good news is that he may also start to be interested in other foods as he gets older–it just takes time and patience, and I would for sure let him lead the way, and just make stuff available to him and talk about what YOU like and are eating.